723-62-6
- Product Name：9-Anthracenecarboxylic Acid
- Molecular Formula：C15H10O2
- Purity：99%
- Molecular Weight：222.243
Product Details
pd_meltingpoint:214-218 °C
Appearance:yellow powder
Purity:99%
Chinese Manufacturer supply 9-Anthracenecarboxylic Acid 723-62-6 in stock with high standard
- Molecular Formula:C15H10O2
- Molecular Weight:222.243
- Appearance/Colour:yellow powder
- Vapor Pressure:1.53E-09mmHg at 25°C
- Melting Point:214-218 °C
- Refractive Index:1.6600 (estimate)
- Boiling Point:467.5 °C at 760 mmHg
- PKA:pK1: 3.65 (25°C)
- Flash Point:206.1 °C
- PSA：37.30000
- Density:1.305 g/cm3
- LogP:3.69120
Anthracene-9-carboxylic acid(Cas 723-62-6) Usage
|
Synthesis Reference(s) |
Journal of the American Chemical Society, 70, p. 1079, 1948 DOI: 10.1021/ja01183a061 |
|
Biological Activity |
Cl - transport inhibitor with a moderate to strong inhibitory action on PKA activated cardiac I cI . |
|
Safety Profile |
Moderately toxic byintraperitoneal route. Mutation data reported. Whenheated to decomposition it emits acrid smoke andirritating vapors. |
|
Purification Methods |
Crystallise the acid from EtOH. It is fluorescent in EtOH. [Beilstein 9 IV 2671.] |
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General Description |
Anthracene-9-carboxylic acid (9-ANCA) is a fluorescent compound derived from the oxidation of 9-anthracenecarboxaldehyde, exhibiting utility in analytical and biochemical applications. It serves as a fluorophore in competitive binding assays, such as the detection of adenosine 5′-monophosphate (AMP) via fluorescence enhancement when displaced from cetyl trimethyl ammonium bromide (CTAB) complexes. Additionally, it is a metabolic product of cytochrome P450 (CYP) enzymes, particularly CYP3A, CYP2A6, and CYP2B6, acting as a probe substrate for enzyme activity assays due to its high sensitivity in fluorimetric detection. Its photophysical properties, including aggregation-induced emission and ratiometric signaling, make it valuable in oxidative sensing, such as chlorite detection, and in photodegradable metal-organic frameworks for controlled drug delivery. |
|
Definition |
ChEBI: An anthroic acid carrying the carboxy substituent at position 9. |
InChI:InChI=1/C15H10O2.Na/c16-15(17)14-12-7-3-1-5-10(12)9-11-6-2-4-8-13(11)14;/h1-9H,(H,16,17);/q;+1/p-1
723-62-6 Relevant articles
Fluorometric analysis of chlorite via oxidation of 9-anthracenecarboxaldehyde
Lee, Kang Min,Choi, Myung Gil,Yoo, Jae Hoon,Ahn, Sangdoo,Chang, Suk-Kyu
, (2021)
We investigated a simple fluorescence si...
Fluorescence enhancement effect for the determination of adenosine 5′-monophosphate with 9-anthracene carboxylic acid-cetyl trimethyl ammonium bromide system
Khot, Mahadev S.,Desai, Netaji K.,Kolekar, Govind B.,Patil, Shivajirao R.
, p. 1997 - 2003 (2011)
A fluorimetric method based on fluoresce...
4-Biphenylaldehyde and 9-anthraldehyde: Two fluorescent substrates for determining P450 enzyme activities in rat and human
Marini,Grasso,Longo,Puccini,Riccardi,Gervasi, P. Giovanni
, p. 1 - 11 (2003)
1. 4-Biphenylaldehyde (4-BA) and 9-anthr...
On-Demand Degradation of Metal-Organic Framework Based on Photocleavable Dianthracene-Based Ligand
Collet, Guillaume,Lathion, Timothée,Besnard, Céline,Piguet, Claude,Petoud, Stéphane
, p. 10820 - 10828 (2018)
We have designed a rigid photocleavable ...
Synthesis method of 9-anthracenecarboxylic acid
-
Paragraph 0031; 0032; 0036-0041, (2022/01/07)
The present invention relates to the fie...
Surface active ionic liquid assisted metal-free electrocatalytic-carboxylation in aqueous phase: A sustainable approach for CO2utilization paired with electro-detoxification of halocarbons
Bhat, Khursheed Ahmad,Bhat, Mohsin Ahmad,Bhat, Sajad Ahmad,Ingole, Pravin P.,Manzoor Bhat, Zahid,Pandit, Sarwar Ahmad,Rather, Mudasir Ahmad,Rehman, Shakeel U.,Sofi, Feroz Ahmad,Thotiyl, Musthafa Ottakam
, p. 9992 - 10005 (2021/12/24)
Electrocarboxylation of halocarbons is a...
Efficient aerobic photooxygenation of aldehydes to carboxylic acids using cobalt(II) phthalocyanine sulfonate as a photosensitizer in organic-water biphasic media
Hajimohammadi, Mahdi,Ahmadi Khamesi, Zahra,Nosrati, Parisa
, p. 167 - 173 (2018/10/31)
The aerobic oxidation of a variety of ar...
723-62-6 Process route
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642-31-9
9-anthracene aldehyde
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-
723-62-6
anthracen-9-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
cobalt(II) 2,9,16,23-phthalocyanine tetrasulfonic acid;
In
water; acetonitrile;
at 20 ℃;
for 150h;
under 760.051 Torr;
UV-irradiation;
|
100% |
|
With
(bipyH2)-CrOCl5;
In
dichloromethane;
at 28 - 30 ℃;
for 12h;
|
95% |
|
With
dihydrogen peroxide;
In
water; acetonitrile;
at 45 ℃;
for 1h;
chemoselective reaction;
|
78% |
|
With
tert.-butylhydroperoxide; selenium(IV) oxide;
In
tert-butyl alcohol;
at 75 ℃;
|
78% |
|
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; water;
In
isopropyl alcohol;
at 20 - 30 ℃;
for 2h;
|
69.65% |
|
With
2-mesityl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; 1,4-diaza-bicyclo[2.2.2]octane; oxygen;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
|
64% |
|
With
sodium hydroxide; silver(l) oxide;
|
|
|
With
silver(l) oxide;
In
ethanol;
|
|
|
With
D-glucose 6-phosphate; rat hepatic microsomes; NADP;
glucose 6-phosphate dehydrogenase;
In
phosphate buffer;
at 37 ℃;
for 0.25h;
pH=7.4;
Further Variations:;
Reagents;
Enzyme kinetics;
|
|
|
9-anthracene aldehyde;
With
ammonia;
at -33 ℃;
for 1h;
Inert atmosphere;
With
potassium permanganate;
for 1h;
Inert atmosphere;
Reflux;
|
|
|
With
chlorite; dimethyl sulfoxide; sodium hydroxide;
In
water;
pH=3;
|
-
-
124-38-9,18923-20-1
carbon dioxide
-
-
723-62-6
anthracen-9-carboxylic acid
| Conditions | Yield |
|---|---|
|
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
carbon dioxide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.5h;
Inert atmosphere;
|
86% |
723-62-6 Upstream products
-
79-37-8
oxalyl dichloride
-
120-12-7
anthracene
-
1564-64-3
9-Bromoanthracene
-
15719-64-9
methylammonium carbonate
723-62-6 Downstream products
-
102183-05-1
10-(4-chloro-phenyl)-anthracene-9-carboxylic acid
-
6929-81-3
10-bromo-9-anthracenecarboxylic acid
-
2141-42-6
1,2,3,4-tetrahydroanthracene
-
1079-71-6
1,2,3,4,5,6,7,8-octahydroanthracene
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