What is the Methyl bromoacetate?

Methyl bromoacetate is clear to slightly yellow liquid, while it's Molecular Formula is C3H5BrO2. clear to slightly yellow liquid Methyl bromoacetate is used in the synthesis of coumarins and cis-cyclopropanes. It reacts with the conjugate base of (methylmethoxycarbene)pentacarbonylchromium(0) to prepare alkylated carbene complexes. Further, it is used to make vitamins and pharmaceuticals.

What is the CAS number for Methyl bromoacetate?

The CAS number of Methyl bromoacetate is 96-32-2.

What is Methyl bromoacetate (96-32-2) used for?

Methyl bromoacetate (also known as bromoacetic acid methyl ester, methyl 2-bromoethanoate, or methyl α-bromoacetate) is a versatile alkylating agent used in organic synthesis, particularly in the formation of esters and heterocyclic compounds. It serves as a key reagent in reactions such as alkylation and ring-closure transformations, as demonstrated in studies involving the synthesis of pyrrolo[2,1-c][1,4]benzodiazocine and trifluoromethylated pyridazine derivatives. Its reactivity with nucleophilic centers makes it valuable for constructing pharmacologically relevant scaffolds, contributing to the development of potential bioactive molecules.InChI:InChI=1/C3H5BrO2/c1-6-3(5)2-4/h2H2,1H3

What is the Methyl bromoacetate?

Methyl bromoacetate is clear to slightly yellow liquid, while it's Molecular Formula is C3H5BrO2. clear to slightly yellow liquid Methyl bromoacetate is used in the synthesis of coumarins and cis-cyclopropanes. It reacts with the conjugate base of (methylmethoxycarbene)pentacarbonylchromium(0) to prepare alkylated carbene complexes. Further, it is used to make vitamins and pharmaceuticals.

What is the CAS number for Methyl bromoacetate?

The CAS number of Methyl bromoacetate is 96-32-2.

What is Methyl bromoacetate (96-32-2) used for?

Methyl bromoacetate (also known as bromoacetic acid methyl ester, methyl 2-bromoethanoate, or methyl α-bromoacetate) is a versatile alkylating agent used in organic synthesis, particularly in the formation of esters and heterocyclic compounds. It serves as a key reagent in reactions such as alkylation and ring-closure transformations, as demonstrated in studies involving the synthesis of pyrrolo[2,1-c][1,4]benzodiazocine and trifluoromethylated pyridazine derivatives. Its reactivity with nucleophilic centers makes it valuable for constructing pharmacologically relevant scaffolds, contributing to the development of potential bioactive molecules.InChI:InChI=1/C3H5BrO2/c1-6-3(5)2-4/h2H2,1H3

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96-32-2

Product Name：Methyl bromoacetate
Molecular Formula：C₃H₅BrO₂
Purity：99%
Molecular Weight：152.975

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Product Details

pd_meltingpoint:-50°C

Appearance:clear to slightly yellow liquid

Purity:99%

Bulk supply high purity Methyl bromoacetate 96-32-2, Paid sample available

Molecular Formula:C3H5BrO2
Molecular Weight:152.975
Appearance/Colour:clear to slightly yellow liquid
Vapor Pressure:3.25mmHg at 25°C
Melting Point:-50°C
Refractive Index:n20/D 1.458(lit.)
Boiling Point:154 °C at 760 mmHg
Flash Point:62.8 °C
PSA：26.30000
Density:1.615 g/cm³
LogP:0.55430

Methyl bromoacetate(Cas 96-32-2) Usage

Application	Methyl Bromoacetate is an organic building block that has been used as a reactant in the preparation of isoquinolinone indole acetic acid derivatives as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.
General Description	A colorless to straw-colored liquid with a sharp penetrating odor. Denser than water and soluble in water. Severly irritates skin and eyes. Toxic by ingestion and inhalation. Used to make vitamins and pharmaceuticals.
Reactivity Profile	Methyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Hazard	Vapor is strong irritant to eyes.
Safety Profile	Poison by intravenous route. When heated to decomposition it emits toxic fumes of Br-. See also ESTERS.

InChI:InChI=1/C3H5BrO2/c1-6-3(5)2-4/h2H2,1H3

96-32-2 Relevant articles

Enantioselective Allenoate-Claisen Rearrangement Using Chiral Phosphate Catalysts

Ellwart, Mario,Gensch, Tobias,Han, Seo-Jung,Lin, Hsin-Hui,Miró, Javier,Sigman, Matthew S.,Toste, F. Dean

supporting information, p. 6390 - 6399 (2020/04/27)

Herein we report the first highly enanti...

Photoinduced Intermolecular [4+2] Cycloaddition Reaction for Construction of Benzobicyclo[2.2.2]octane Skeletons

Liu, Qiang,Wang, Junlei,Li, Dazhi,Yang, Chao,Xia, Wujiong

, p. 1389 - 1402 (2017/02/10)

A novel and efficient method for the syn...

Phosphine-Catalyzed Domino β/γ-Additions of Benzofuranones with Allenoates: A Method for Unsymmetrical 3,3-Disubstituted Benzofuranones

Huang, Zhusheng,Yang, Xiuqin,Yang, Fulai,Lu, Tao,Zhou, Qingfa

supporting information, p. 3524 - 3527 (2017/07/17)

A phosphine-catalyzed domino process of ...

Synthesis of 1,4-enamino ketones by [3,3]-rearrangements of dialkenylhydroxylamines

Pecak, Wiktoria H.,Son, Jongwoo,Burnstine, Amy J.,Anderson, Laura L.

supporting information, p. 3440 - 3443 (2014/07/21)

The synthesis of 1,4-enamino ketones has...

96-32-2 Process route

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 74-95-3
1,1-dibromomethane

: 109-87-5
Dimethoxymethane

: 6290-49-9
methyl methoxyacetate

: 96-32-2
bromoacetic acid methyl ester

: 108-59-8
malonic acid dimethyl ester

Conditions

Conditions	Yield
With sodium hydroxide; carbon-doped cobalt; at 140 ℃; for 1h; under 23560 Torr; Further byproducts given;	34.4 % Chromat. 0.8 % Chromat. 47.6 % Chromat. 22.2 % Chromat.